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Wednesday, July 5, 2017

All About Vitamins: Vitamin A and Complications of Coronary Artery Disease

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin A, a bi-polar molecule formed by bonds between carbon and hydrogen, is a fat soluble vitamin which can not be stored in the liver but it can be converted from beta-carotene, a powerful antioxidant. The vitamin is best known fir its strong effects in improving vision and enhancing bone growth.

Low level of serum of Retinoic acid (RA) is found to associate to the risk of the development of Coronary Artery Disease and its complications in patients with such disease, according to Gaziosmanpaşa University.

And serum of Retinoic acid (RA) in patient with coronary Artery Disease may be associate to the increased risk of morality, the measured serum RA concentrations in 1499 patients with angiographically confirmed coronary artery disease(mean age, 61 years; male, 67%) recruited from October 2008 and December 2011 in the Guangdong Coronary Artery Disease Cohort suggested.

Coronary Artery Disease is a condition of heart muscle become hardened and narrowed of that can increased risk of blood oxygen levels and blood flow cause of heart diseases.

Some researchers in the study of the risk of coronary Artery Disease and its complications suggested maintaining serum vitamin A levels less than 30 μg/dL or greater than 80 μg/dL levels may be the best way to prevent risk of all-cause mortality and coronary artery disease-related mortality.

Dr. Min KB,and Dr. Min JY. said, "Comparing the normal range of serum vitamin A, the hazard ratio with deficient serum vitamin A was 2.9 (95% CI 2.0-4.3) for all-cause mortality, 2.1 (95% CI 1.1-4.1) for cardiovascular-related mortality and 2.5 (95% CI 1.2-5.3) for coronary artery disease-related mortality" and " Excessive serum vitamin A was associated with a 1.2-fold (95% CI 1.1-1.4) increased risk of all-cause mortality, a 1.4-fold (95% CI 1.2-1.8) increased risk of cardiovascular-related mortality, and a 1.5-fold (95% CI 1.2-2.0) increased risk of coronary artery disease-related mortality".

Taking altogether, the risk of developed Coronary Artery Disease and induced complications of patients with such diseases may be a result of vitamin A deficiency or  a significant high levels of plasma of vitamin A in the body. Therefore, intake of large amount of vitamin A supplement can only  be prescribed by medical doctors.

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(1) The association of plasma vitamin A and E levels with coronary collateral circulation by Söğüt E1, Kadı H2, Karayakalı M2, Mertoğlu C3(PubMed)
(2) Association of Serum Retinoic Acid With Risk of Mortality in Patients With Coronary Artery Disease by Liu Y1, Chen H1, Mu D1, Li D1, Zhong Y1, Jiang N1, Zhang Y1, Xia M2.(PubMed)
(3) Relation of serum vitamin A levels to all-cause and cause-specific mortality among older adults in the NHANES III population by Min KB1, Min JY2.(PubMed)

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