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Monday, July 24, 2017

All About Vitamins: High Dose of Thiamine(Vitamin B1) in Reduced Risk of Neurodegeneration

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B1, also known as thiamin or thiamine, one of the members of the vitamin B complex is a colorless chemical compound with the formula C12H17N4OS., discovered in 1910 by Umetaro Suzuki in Japan. Vitamin B1 is a water soluble vitamin.

Vitamin B1 is found to associate to prevent neurodegeneraive diseases, a recently study conducted by a renown institute suggested.

According to the joint study lead by the Aichi Human Service Center, mice fed with thiamine-restricted diet (thiamine: 0.60 mg/100 g food) died within 30 and 12 days period respectively, induced the dramatically decreased thiamine concentration in the blood and brain, causing acute neurodegeneration.

The development of thiamine metabolism dysfunction syndrome 2(THMD2) exerted anti neurodegeneration probably is the result of thiamine-restricted diet in ameliorate the levels of thiamine (vitamin B1) derivative, namely the thiamine pyrophosphate.

Dr. Suzuki K, the lead author said, "acute neurodegeneration caused by thiamine deficiency is preventable in most parts, and prompt high-dose thiamine administration is critical for the treatment of THMD2".

In fact, reduced thiamine levels can also promote AD-like abnormalities, including memory deficits, neuritic plaques, and hyperphosphorylation of tau. In the study of classical thiamine deficiency and dementia, thiamine deficiency is associate to cognitive deficits and reductions in brain glucose metabolism, affecting function of the thiamine-dependent enzymes.

Researchers at the study also found that drugs or other manipulations interfered with thiamine absorption can cause thiamine deficiency and excess thiamine intake may diminishes AD-like diseases.

In animal models, thiamine deficiency elevates plaque formation, promotes phosphorylation of tau and impairs memory. In contrast, treatment with the thiamine derivative benfotiamine diminishes plaques, decreases phosphorylation of tau and reverses memory deficits..
Therefore, there is no doubt that thiamine deficiency diet may induce the development and progression of neuro degenerative diseases, but doses intake should only be prescribed by medical doctors.

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(1) High-dose thiamine prevents brain lesions and prolongs survival of Slc19a3-deficient mice by Suzuki K1, Yamada K1, Fukuhara Y1, Tsuji A2, Shibata K2, Wakamatsu N1.(PubMed)
(2) Vitamin B1 (thiamine) and dementia by Gibson GE1, Hirsch JA2, Fonzetti P2, Jordan BD2, Cirio RT2, Elder J1.(PubMed)
(3) Abnormal thiamine-dependent processes in Alzheimer's Disease. Lessons from diabetes by Gibson GE1, Hirsch JA, Cirio RT, Jordan BD, Fonzetti P, Elder J.(PubMed)

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