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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.
Vitamin B1 or thiamine deficiency is found to associated to high risk of over 50% in heart failure (HF).
According to the cross-sectional study was conducted in 30 HF patients scheduled for regular follow-up visits in the Mayo Heart Failure Clinic, the prevalence of thiamine deficiency in stable HF patients was calculated to be <11.6%.. High doses of thiamine supplementation improved myocardial function and may be become conditionally essential with HF.
In a systematic review of the literature and a meta-analysis to evaluate the prevalence of thiamine deficiency (TD) in HF patients, TD is more common in HF patients than control subjects (odds ratio 2.53, 95% confidence interval 1.65-3.87) and intake of vitamin B1 of these patients are found to associate to improve ejection fraction and reduce symptoms.
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(1) Prevalence of thiamine deficiency in a stable heart failure outpatient cohort on standard loop diuretic therapy by Teigen LM1, Twernbold DD2, Miller WL3.(PubMed)
(2) Determining the Role of Thiamine Deficiency in Systolic Heart Failure: A Meta-Analysis and Systematic Review by Jain A1, Mehta R2, Al-Ani M3, Hill JA4, Winchester DE4(PubMed)
(3) Does Long-Term Furosemide Therapy Cause Thiamine Deficiency in Patients with Heart Failure? A Focused Review by Katta N1, Balla S1, Alpert MA2.(PubMed)