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Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.
Oxidative stress is essentially an imbalance between the production of free radicals and levels of antioxidant, which plays an important role in neutralized the domino's process causes of varies diseases.
Thiamine deficiency induced production of oxidative stress has found to associate to the development of structural lesions, including excitotoxicity, neuroinflammation, blood-brain barrier integrity, mitochondrial integrity, apoptosis, nucleic acid function, the renowned institute study suggested.
The study also suggested that reverse of brain immature neuron is the result of function of thiamine and thiamine derivative in protected the brain tissues against paraquat-induced oxidative stress.
Furthermore, thiamine compounds function in boosting anti-oxidant cellular defenses of the test subjects may also express through the prevention of stress-induced inhibition of hippocampal neurogenesis and accompanying physiological changes.
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(1) The impact of oxidative stress in thiamine deficiency: a multifactorial targeting issue by Hazell AS1, Faim S, Wertheimer G, Silva VR, Marques CS.(PubMed)
(2) Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels by Vignisse J1, Sambon M1, Gorlova A2, Pavlov D2, Caron N1, Malgrange B1, Shevtsova E3, Svistunov A2, Anthony DC4, Markova N5, Bazhenova N6, Coumans B1, Lakaye B1, Wins P1, Strekalova T7, Bettendorff L8.(PubMed)