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Tuesday, July 25, 2017

All About Vitamins: Thiamine Reduced Risk of Oxidative Stress

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.

Oxidative stress is essentially an imbalance between the production of free radicals and levels of antioxidant, which plays an important role in neutralized the domino's process causes of varies diseases.

Thiamine deficiency induced production of oxidative stress has found to associate to the development of structural lesions, including excitotoxicity, neuroinflammation, blood-brain barrier integrity, mitochondrial integrity, apoptosis, nucleic acid function, the renowned institute study suggested.

According to the joint study lead by the University of Liege, thiamine is essential for normal brain function and its deficiency causes metabolic impairment, specific lesions, oxidative damage and reduced adult hippocampal neurogenesis (AHN). 

In C57BL6/J mice with predator stress for 5 consecutive nights, new born babies showed a significant abnormality of brain lesion of immature neurons but the recovery of this process is promptly reduced when the mice were treated (200mg/kg/day in drinking water for 20days) with thiamine or benfotiamine.

The study also suggested that reverse of brain immature neuron is the result of function of thiamine and thiamine derivative in protected the brain tissues against paraquat-induced oxidative stress.

Furthermore, thiamine compounds function in boosting anti-oxidant cellular defenses of the test subjects may also express through the prevention of stress-induced inhibition of hippocampal neurogenesis and accompanying physiological changes.

Taking together, thiamine and benfotiamine, a derivative of thiamine have played an important role in the development of brain neurons of the new born and prevention of oxidative stress in induction of brain tissues damage.

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(1) The impact of oxidative stress in thiamine deficiency: a multifactorial targeting issue by Hazell AS1, Faim S, Wertheimer G, Silva VR, Marques CS.(PubMed)
(2) Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels by Vignisse J1, Sambon M1, Gorlova A2, Pavlov D2, Caron N1, Malgrange B1, Shevtsova E3, Svistunov A2, Anthony DC4, Markova N5, Bazhenova N6, Coumans B1, Lakaye B1, Wins P1, Strekalova T7, Bettendorff L8.(PubMed)

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