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Sunday, July 16, 2017

All About #CurableVitamins: Vitamin B1 Anti Inflammatory effects

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.

Recent study suggested that vitamin B1 may process a anti inflammatory properties in binding to pro inflammatory cytokins.
In a diethylnitrosamine (DEN)-induced HCC in Wistar rats, after 12 weeks of treatment study, combination of pure ibuprofen (40 mg/kg) and thiamine possesses the significant chemoprotective effect by restoring the hepatic enzymes and alteration in pro-inflammatory cytokines.

Benfotiamine is a synthetic vitamin B1 (thiamine) found to regulate the activation of microglia, a type of neuroglia cell) in protection against neurodegeneration by inhibiting inflammatory mediators and enhancing anti-inflammatory factor.

Furthermore, according to the Instituto Mexicano del Seguro Social, Mexico City, thiamine (100 mg) used conjuction with other B vitamin in comparison with diclofenac, Diclofenac+B vitamins mixture showed a superior analgesic effect during the assessed period and also a better assessment of the pain relief perception by patients than diclofenac alone.

The analgesic effect of diclofenac by B vitamins in patients also improved the osteoarthritis programmed to total knee arthroplasty, as a clinical model of inflammatory pain.

Moreover, intake of thiamine intake after 7 days also yielded a significant itch relief and combination of cobalamin and thiamine combination significantly relieved both pain and itch through inhibiting inflammatory activity.

The Affiliated Tenth People's Hospital of Tongji University, Shanghai, suggested, "Sixteen patients in the thiamine group achieved ≥ 30% itch reduction;" and " 18 patients achieved ≥ 30% itch reduction and 19 patients obtained ≥ 30% pain reduction in the combination group".

Taking altogether,  vitamin B1 may p[rocess an anti inflammatory effects in reduced pro-inflammatory cytokines expression cause of certain symptoms but quantity intake should be taken with care.

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(1) Thiamine potentiates chemoprotective effects of ibuprofen in DEN induced hepatic cancer via alteration of oxidative stress and inflammatory mechanism by Afzal M1, Kazmi I2, Khan R3, Rana P3, Kumar V4, Al-Abbasi FA5, Zamzami MA5, Anwar F6.(PubMed)
(2) Benfotiamine attenuates inflammatory response in LPS stimulated BV-2 microglia by Bozic I1, Savic D1, Laketa D2, Bjelobaba I1, Milenkovic I3, Pekovic S1, Nedeljkovic N2, Lavrnja I1.(PubMed)
(3) B-vitamin mixture improves the analgesic effect of diclofenac in patients with osteoarthritis: a double blind study by Magaña-Villa MC1, Rocha-González HI, Fernández del Valle-Laisequilla C, Granados-Soto V, Rodríguez-Silverio J, Flores-Murrieta FJ, Carrasco-Portugal MC, Reyes-García JG.(PubMed)

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