All About #CurableVitamins: Vitamin B1 Deficiency Associated to the Risk of Alzheimer's disease(AD)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.

Alzheimer's disease (AD) patients is associated to impaired thiamine metabolites in energy metabolism and activities of thiamine-dependent enzymes (thiamine diphosphate (TDP)) in production of thiamine derivative.

In the recruited 45 AD patients clinically diagnosed and 38 age- and gender-matched control subjects without dementia study, the joint study lead by the Fudan University found that blood TDP contents of AD patients were significantly lower than those in control subjects (79.03 ± 23.24 vs. 127.60 ± 22.65 nmol/L, P<0.0001.

Dr. Pan X, the lead author in the joint study suggested, the imbalance activities of thiamine induced by addition and removal in monophosphatase (TMPase) and thiamine diphosphatase (TDPase) may be directly involved in thiamine and glucose metabolism.

In fact, vitamin deficiencies are causative for AD development, many researchers recommended that they should be tested for early detectable in patient with AD.

Thiamine deficiency (TD) result from inadequate intake, increased requirement, excessive deletion, and chronic alcohol consumption, according to the Shandong University School of Medicine, may play an critical role in central and peripheral nervous systems induced neuro-degenerative diseases, such as Alzheimer's disease(AD), Parkinson's disease (PD), and Huntington's disease (HD), through induced  oxidative stress and impaired natural, regulated, destructive mechanism of the cell in the brain.

There is no doubt that thiamine deficiency is associated to patients with Alzheimer's disease(AD). treatment of high quantity amount of thiamine should only be prescribed by related field specialist.

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Sources
(1) Enhanced Activities of Blood Thiamine Diphosphatase and Monophosphatase in Alzheimer's Disease by Pan X1,2, Sang S1,2, Fei G1, Jin L1, Liu H2, Wang Z3, Wang H3, Zhong C1,2.(PubMed)
92) Thiamine Deficiency and Neurodegeneration: the Interplay Among Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy by Liu D1,2, Ke Z3, Luo J4,5.(PubMed)