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Thursday, July 6, 2017

All About Vitamins: Vitamin A and Lung cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin A, a bi-polar molecule formed by bonds between carbon and hydrogen, is a fat soluble vitamin which can not be stored in the liver but it can be converted from beta-carotene, a powerful antioxidant. The vitamin is best known fir its strong effects in improving vision and enhancing bone growth.

Provitamin A carotenoid β-cryptoxanthin (BCX) supplement may be associate to lower risk and treatment of lung cancer. 
According to Tufts University, BCX significantly reduced the multiplicity of the NNK-induced lung tumor by 52% to 63% compared with the NNK-treated mice without BCX supplementation, in the study of 4-[methyl nitrosamino]-1-[3-pyridyl]-1-butanone (NNK)-induced lung tumorigenesis in A/J mice.

Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers are derived from epithelial cells. In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistic.

Dr. Iskandar AR, the lead researchers said, "The activities of BCX were significantly attenuated by activators of α7-nAChR/PI3K(immune system) signaling or by overexpression of constitutively active PI3K(cell cycle division). Collectively, the results suggest that BCX inhibits".

Other researchers suggested that over expression of lung cancer tissues may be also associate to the abnormal function of retinoid metabolism. caused by changes in the expression of 23 genes that regulate retinoid metabolism and signaling in non-small-cell lung cancer tumors compared to adjacent normal tissues.

The random-effect model used to estimate the relative risk (RR) and their 95% CI in a total of 19 studies comprising 10,261 lung cancer cases met the inclusion criteria, insisted higher category of dietary β-carotene intake could reduce lung cancer risk (0.768 (0.675-0.874)).
The associations were also significant in American and Asian populations. In conclusions, higher category of dietary β-carotene and vitamin A intakes could reduce the risk of lung cancer.

In fact, risk of lung cancer is increased for smokers as the result of depletion of vitamin A in the body induced imbalance of protein expression in the retinoic acid receptor.

Taking altogether, dietary vitamin A exposure,  change life style are associate to reduced risk of lund cancer while vitamin A deficiency is increased risk of the diseases.

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(1) β-Cryptoxanthin Reduced Lung Tumor Multiplicity and Inhibited Lung Cancer Cell Motility by Downregulating Nicotinic Acetylcholine Receptor α7 Signaling by Iskandar AR1, Miao B1, Li X1, Hu KQ1, Liu C1, Wang XD2.(PubMed)
(2) [Abnormal expression of genes that regulate retinoid metabolism and signaling in non-small-cell lung cancer].[Article in Russian]by Kuznetsova ES1, Zinovieva OL1, Oparina NY1, Prokofjeva MM1, Spirin PV1, Favorskaya IA2, Zborovskaya IB2, Lisitsyn NA1, Prassolov VS1, Mashkova TD1,3.(PubMed)
(3) Association of Dietary Vitamin A and β-Carotene Intake with the Risk of Lung Cancer: A Meta-Analysis of 19 Publications by Yu N1, Su X2, Wang Z3, Dai B4, Kang J5.(PubMed)
(4) Vitamin A depletion induced by cigarette smoke is associated with an increase in lung cancer-related markers in rats by Xue Y1, Harris E2, Wang W3, Baybutt RC4,5.(PubMed)

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