Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.
Thiamine Deficiency induced oxidative and stress and the natural, regulated, destructive mechanism of the cell in the brain, which are known to contribute to the pathogenesis of various neurodegenerative diseases.
According to the joint study, lead by Shandong University School of Medicine, Thiamine deficiency is kown to cause a cascade of events including mild impairment of oxidative metabolism, neuroinflammation, and neurodegeneration, which are commonly observed in neurodegenerative diseases, such as Alzheimer's disease(AD), Parkinson's disease (PD), and Huntington's disease (HD).
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(1) Thiamine Deficiency and Neurodegeneration: the Interplay Among Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy by Liu D1,2, Ke Z3, Luo J4,5.(PubMed)
(2) High-dose thiamine prevents brain lesions and prolongs survival of Slc19a3-deficient mice by Suzuki K1, Yamada K1, Fukuhara Y1, Tsuji A2, Shibata K2, Wakamatsu N1.(PubMed)