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Wednesday, July 12, 2017

All About #CurableVitamins: Vitamin B1 in Managing Diabetic Complications

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.

Intake of  Vitamin B1( thiamine) may be beneficiary for patients with diabetes in management of diabetic complications

Diabetes is a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

In a total of Fifty-six 6-week-old female mice, divided into seven groups of eight animals, with diabetes induced in fasted mice by using intraperitoneal (IP) injection of alloxan (180 mg/kg), mice treated with thiamine expressed a decreasing blood glucose, lower serum triglyceride (TG), LDL, and total cholesterol (TC) levels.

Dr. Amiri A said, "... and thiamine are potent antidiabetic factors, and that, these compound supplementation possesses hypoglycemic properties and have effect on serum lipid parameters in diabetes mice".

In patients with gene 2 (SLC19A2) mutation causes of permanent neonatal diabetes, intake of thiamine supplementation not only can corrected insulin insufficiency but also reduced complications of anemia or hearing defects.

Furthermore, also in patients with gene 2 (SLC19A2) mutation, thiamine supplementation showed a preventive effect on hematological disorders over a few years in both pediatric subjects, and improved glycaemic control of diabetes mellitus.

Taking altogether, intake of oral supplement of vitamin B1 in patients with diabetes may have a positive effect in managing diabetic complications, but quantity control is necessary to prevent overdoses.

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(1) Effect of the Zinc Oxide Nanoparticles and Thiamine for the Management of Diabetes in Alloxan-Induced Mice: a Stereological and Biochemical Study by Amiri A1, Dehkordi RAF2, Heidarnejad MS3, Dehkordi MJ4.(PubMed)
(2) Recovered insulin production after thiamine administration in permanent neonatal diabetes mellitus with a novel solute carrier family 19 member 2 (SLC19A2) mutation by Sun C1, Pei Z1, Zhang M1, Sun B2, Yang L1,2, Zhao Z1, Cheng R1, Luo F1.(PubMed)

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