All About Vitamins: Thiamine in Reduced Risk of Vascular Disease

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.

The association of thiamine deficiency among diabetes mellitus without treatment may increased risk of vascular disease involving blood vessels – the arteries and veins of the circulatory system.

According to the Queen Alexandra Hospital, thiamine deficiency may lead to hyperglycaemic-induced damage, affecting vascular disease in promoting cardiovascular risk.

In a study of diabetic patients (26 type 1 and 48 type 2) with and without microalbuminuria and 20 normal healthy control volunteers, researchers found that decrease plasma volumes are associated to patients with diabetes as shown in the scale. Patient with diabetes showed a plasma thiamine concentration decreased 76% in type 1 diabetic patients and 75% in type 2 diabetic patients in compared to normal volunteers.

Diabetic patients also showed an increased urinary excretion of thiamine, which may be a leading cause of thiamine deficiency.

Dr. Thornalley PJ, the lead author said, "low plasma thiamine concentration is prevalent in patients with type 1 and type 2 diabetes, associated with increased thiamine clearance".

Taking altogether, low plasma thiamine concentration in diabetic patients showed to increased risk of vascular disease. Intake of high dose thiamine may be beneficiary to dysfunction of intracellular transport or enzymatic abnormalities in ameliorate the development of vascular dysfunction in inducing stroke.

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Sources
(1) Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease by Page GL1, Laight D, Cummings MH.(PubMed)
(2) High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease by Thornalley PJ1, Babaei-Jadidi R, Al Ali H, Rabbani N, Antonysunil A, Larkin J, Ahmed A, Rayman G, Bodmer CW.(PubMed)
(3) High-dose thiamine improves fatigue after stroke: a report of three cases by Costantini A1, Pala MI, Catalano ML, Notarangelo C, Careddu P.(PubMed)