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Monday, July 10, 2017

All About #CurableVitamins: The role of Carotenoids in Anti inflammatory activities

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin A, a bi-polar molecule formed by bonds between carbon and hydrogen, is a fat soluble vitamin which can not be stored in the liver but it can be converted from beta-carotene, a powerful antioxidant. The vitamin is best known fir its strong effects in improving vision and enhancing bone growth.

Carotenoids, included carotene, are the group of orange pigments phytochemical played an important role as precursors of vitamin A.

Recent study suggested that dietary carotenoids is found to inhibited inflammatory cytokines in reduced risk of chronic diseases, such as CVD.
According to the joint study lead by the University of Bari, the result of inflammatory effect of carotenoids probably due to their free radicals scavenger properties and improved low-density lipoprotein cholesterol resistance to oxidation.
Dr Krinsky NI and Dr. Johnson EJ., in the study of health effects of carotenoid actions, said," the beneficial effects of carotenoids are thought to be due to their role as antioxidants. beta-Carotene may have added benefits due its ability to be converted to vitamin A. Additionally, lutein and zeaxanthin may be protective in eye disease because they absorb damaging blue light that enters the eye".

In the measured plasma from 134 patients with stable angina (SA) and 59 patients with acute coronary syndrome, the carotenoid derivative showed a inverse correlation with inflammatory cytokine IL-6 in SA patients at baseline (r = -0.366, p < 0.001) and follow-up (r = -0.546, p < 0.001).
Furthermore, in patient with schizophrenia, carotenoids inhibited inflammation and oxidative stress in regualted the function of pro-inflammatory cytokines involved central nervous development and proper functioning of neural networks and neurotransmitters.

Due to benefits of the precursor, instead of intake of vitamin A supplement, many researchers recommend that paients with vitamin A deficiency should increase intake of fruits and vegetables with rich of vitamin A.

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(1) Dietary intake of carotenoids and their antioxidant and anti-inflammatory effects in cardiovascular care by Ciccone MM1, Cortese F1, Gesualdo M1, Carbonara S1, Zito A1, Ricci G1, De Pascalis F1, Scicchitano P1, Riccioni G2.(PubMed)
(2) Carotenoid actions and their relation to health and disease by Krinsky NI1, Johnson EJ.(PubMed)
(3) Lutein exerts anti-inflammatory effects in patients with coronary artery disease by Chung RWS1, Leanderson P2, Lundberg AK3, Jonasson L3.(PubMed)
94) Antioxidant and anti-inflammatory nutrient status, supplementation, and mechanisms in patients with schizophrenia by Mitra S1, Natarajan R1, Ziedonis D1, Fan X2.(PubMed)

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