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Thursday, March 24, 2016

The #CurableSmoothie of Blueberry, Tomato, Turmeric and Grape Juice for Prevention and Treatment of Neonatal Hepatitis

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of  Neonatal Hepatitis
Yield: 2 servings (about 8 ounces each)
3/4  cup blue berry
3/4 cup tomato
1 tsp curcumin
1 cup grape juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of   Neonatal Hepatitis has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Neonatal Hepatitis is a condition of liver inflammatory liver diseases occurred in the newborn, mostly within one to two months after birth. According to liver foundation anti viral infection together with intake of vitamin A, D and K should be helpful in fighting of free radicals in induction of oxidative stress(1).

Recent studies back by well known institutions proposed, Blueberry, Tomato, Turmeric and Grape Juice may be the next generation of natural ingredients for prevention and treatment of Neonatal Hepatitis.

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in grape and blueberry may be a potent antioxidant for reduced risk and treatment of neonatal Hepatitis, through its anti viral infection(2). 
Accoridng to the IQ Institute of Infection and Immunity, resveratrol, the anti viral key molecules inhibited against HCV genotype 3a (GT3a) may offer an alternative attraction to target the viral helicase for treatment of hepatitis(3).
In a new human hepatoma cell line system for hepatitis C virus, the anioxidant effectively trigger autophagic cell death through the increased expression of autophagy through cell cycle arrest(4).

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia. The herb has been used in trditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc. Its phytochemical curcumin expressed anti hepatitis B virus (HBV) effect through inhibited HBV gene expression and replication(5).
According to the German Cancer Research Center (DKFZ), curcumin also reduced tumor incidence at other organ sites and suppressed formation of metastases and should be considered as a contra-indicated for patients suffering from inherited and acquired metal storage diseases that include patients with hepatitis C virus infection(6).
Curcuminoids, derived from the plant Curcuma domestica Val derivatives of curcumin, are effective in suppressing the hepatic microvascular inflammatory response against lipopolysacharide (LPS) through ameliorated expression of inflammatory cytokines(7).

Carotenoids, found abundantly in carrot and tomato also attenuated risk and treatment of neonatal hepatitis C through exhibition of synergistic effect(8). According to the Tongji Medical College, Huazhong University of Science and Technology, lutein, a member of carotenoids inhibited the activity of HBV through suppressed the secretion of HBsAg(antigen) from HepG2 2.2.15 cells in a dose-dependent manner(9).
Dr, Mawson AR and Dr. Steele TA., professors at the Des Moines University Osteopathic Medical Center, said, "The reduced rate of survival of liver grafts in patients with HBV infection could also be due to the continued presence of the virus, stimulated by retinoids in the graft tissue. "(10).

The effectiveness of Blueberry, Tomato, Turmeric and Grape Juice  may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Neonatal Hepatitis with little or no adverse effects.
Women who are at high risk of Neonatal Hepatitis due to family history, environment factors, .... should drink at least one serving daily and women with Neonatal Hepatitis should drink the smoothie as much as they can, depending to digestive toleration.
We don't recommend smoothie for newborn
Life style and dietary patter change are recommended.

References
(1) How Is Neonatal Hepatitis Defined?(The liver disorder foundation)
(2) Identification of a resveratrol tetramer as a potent inhibitor of hepatitis C virus helicase by Lee S1, Yoon KD2, Lee M3, Cho Y3, Choi G3, Jang H4, Kim B5, Jung DH6, Oh JG2, Kim GW7, Oh JW7, Jeong YJ6, Kwon HJ5, Bae SK2, Min DH4, Windisch MP3,Heo TH2, Lee C1.(PubMed)
(3) Docking studies of Pakistani HCV NS3 helicase: a possible antiviral drug target. by Fatima K1, Mathew S2, Suhail M3, Ali A3, Damanhouri G3, Azhar E3, Qadri I3.(PubMed)
(4) Resveratrol arrests cell cycle and induces apoptosis in human hepatocellular carcinoma Huh-7 cells by Liao PC1, Ng LT, Lin LT, Richardson CD, Wang GH, Lin CC.(PubMed)
(5) Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1alpha. by Rechtman MM1, Har-Noy O, Bar-Yishay I, Fishman S, Adamovich Y, Shaul Y, Halpern Z, Shlomai A.(PubMed)
(6) No prevention of liver and kidney tumors in Long-Evans Cinnamon rats by dietary curcumin, but inhibition at other sites and of metastases by Frank N1, Knauft J, Amelung F, Nair J, Wesch H, Bartsch H.(PubMed)
(7) Effect of curcuminoids as anti-inflammatory agents on the hepatic microvascular response to endotoxin by Lukita-Atmadja W1, Ito Y, Baker GL, McCuskey RS.(PubMed)
(8) Retinoids and rexinoids inhibit hepatitis C virus independently of retinoid receptor signaling by Murakami Y1, Fukasawa M2, Kaneko Y3, Suzuki T4, Wakita T5, Fukazawa H6.(PubMed)
(9) In vitro antiviral activity of lutein against hepatitis B virus by Pang R1, Tao JY, Zhang SL, Zhao L, Yue X, Wang YF, Ye P, Dong JH, Zhu Y, Wu JG.(PubMed)
(10) Possible role of retinoids in hepatitis B virus-associated liver damage By Mawson AR1, Steele TA.(PubMed)

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