The #CurableSmoothie of Brazil Nut, Olive and Honey for Prevention and Treatment of Chronic Kidney disease, including Mesoamerican nephropathy

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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The smoothie for prevention and treatment of Chronic Kidney disease, including Mesoamerican nephropathy
Yield: 2 servings (about 8 ounces each)
1/ 2 Brazil nut
1/2 olive
1/2 honey
1 cup water

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

Mesoamerican nephropathy is a chronic kidney disease of unknown cause, emerging in the last decade in Central America, inducing chronic tubulointerstitial disease with associated secondary glomerulosclerosis and some signs of glomerular ischemia(9).

The finding of a natural source for treatment of  Mesoamerican nephropathy is a chronic kidney disease has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Chronic Kidney disease is defined as a condition of the progression loss of kidney function over period of many years. Stage of chronic kidney disease according to the National Kidney Foundation's Kidney Disease Outcomes Quality Initiative (KDOQ). According to the George Institute for Global
Health, The presence of antioxidant may induced some benefits, particularly in those on dialysis(1).
Dr. Zachara BA said, "Oxidative stress plays a key role in numerous disease processes including chronic kidney disease (CKD). In general, oxygen metabolism leads to the formation of reactive oxygen species (ROS) dangerous to cells"(2).

Selenium, found abundantly in Brazil nut, was effectively in ameliorated oxidative stress and inflammation in hemodialysis (HD) patients, after 12 months through attenuated 8-isoprostane, 8-OHdG, the free radicals and cytokines, increased and the activity of GPx and expressed selenium plasma levels(3).
According to the Federal University of Rio de Janeiro (UFRJ), hemodialysis (HD) patients may be benefits in consumption of Brazil nut  in 3 months as the study insisted that the procedure not only is effective against the inflammation, oxidative stress markers, and the atherogenic risk, but also improved the antioxidant defenses in HD patients(4).

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers. It is considered as one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people. may also process the property as an antioxidant in reduced the expression of oxidative stress. According to the Universiti Sains Malaysia, "administered alone or in combination with conventional therapy, honey might be a novel antioxidant in the management of chronic diseases commonly associated with oxidative stress"(5).

Dr,. Johnson DW and colleagues suggested, honey may also be effective against antibiotic-resistant microorganisms induced hemodialysis catheters infection of HD patients, topically(6).

Omega 3 fatty acids found abundantly in olive may be used conjunction with a cholesterol-lowering medication atorvastatin for treatment of chronic kidney disease (CKD)(7).
treatment of omega-3 FA-supplemented group after 6 months expressed a clinical benefit of increased vitamin D, fetuin-A levels, and modified erythrocyte membrane FA contents in dialysis patients of that reduced risk complications of vascular calcification and cardiovascular disease.

In patient with Mesoamerican nephropathy, maintaining enough water intake to prevent heat stress, dehydration, biomarkers of renal function and their possible associations may reduced risk of decreased renal blood flow, high demands on tubular reabsorption, and increased levels of uric acid induced kidney damage in progression of kidney failure in sugarcane workers in Central America(9)(10)

The finding of the effectiveness of Brazil Nut, Olive and Honey may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of Chronic Kidney disease, including Mesoamerican nephropathy.

People who are at increased risk of Chronic Kidney disease, including Mesoamerican nephropathy, due to family history, obesity, diabetes,....should drink the juices at least one a day. People with Chronic Kidney disease, including Mesoamerican nephropathy. should drink the juice as much as as they can depending to digestive toleration.
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References
(1) Antioxidants for chronic kidney disease by Jun M1, Venkataraman V, Razavian M, Cooper B, Zoungas S, Ninomiya T, Webster AC, Perkovic V.(PubMed)
(2) Selenium and selenium-dependent antioxidants in chronic kidney disease by Zachara BA1.(PubMed)
(3) A follow-up study of the chronic kidney disease patients treated with Brazil nut: focus on inflammation and oxidative stress by Stockler-Pinto MB1, Malm O, Moraes C, Farage NE, Silva WS, Cozzolino SM, Mafra D.(PubMed)
(4) Brazil nut (Bertholletia excelsa, H.B.K.) improves oxidative stress and inflammation biomarkers in hemodialysis patients. by Stockler-Pinto MB1, Mafra D, Moraes C, Lobo J, Boaventura GT, Farage NE, Silva WS, Cozzolino SF, Malm O.(PubMed)
(5) Honey: a novel antioxidant by Erejuwa OO1, Sulaiman SA, Ab Wahab MS.(PubMed)
(6) Randomized, controlled trial of topical exit-site application of honey (Medihoney) versus mupirocin for the prevention of catheter-associated infections in hemodialysis patients by Johnson DW1, van Eps C, Mudge DW, Wiggins KJ, Armstrong K, Hawley CM, Campbell SB, Isbel NM, Nimmo GR, Gibbs H.(PubMed)
(7) Patient with hypertriglyceridemia, type 2 diabetes, and chronic kidney disease treated with atorvastatin andomega-3 Fatty Acid ethyl esters by Athyros VG1, Mikhailidis DP.(PubMed)

(8)  CKD of unknown origin in Central America: the case for a Mesoamerican nephropathy by Correa-Rotter R1, Wesseling C2, Johnson RJ3.(PubMed)

(9) Heat stress, dehydration, and kidney function in sugarcane cutters in El Salvador--A cross-shift study of workers at risk of Mesoamerican nephropathy by García-Trabanino R1, Jarquín E2, Wesseling C3, Johnson RJ4, González-Quiroz M5, Weiss I6, Glaser J7, José Vindell J8, Stockfelt L9, Roncal C10, Harra T11(PubMed)

(10) Heat Stress Nephropathy From Exercise-Induced Uric Acid Crystalluria: A Perspective on MesoamericanNephropathy by Roncal-Jimenez C1, García-Trabanino R2, Barregard L3, Lanaspa MA1, Wesseling C4, Harra T1, Aragón A5, Grases F6, Jarquin ER7, González MA8, Weiss I9,Glaser J9, Sánchez-Lozada LG10, Johnson RJ11(PubMed)