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The smoothie for prevention and treatment of Thyroid Cancer
Yield: 2 servings (about 8 ounces each)
1 cup grape
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately
The finding of a natural source for treatment of Thyroid Cancer has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.
Thyroid cancer is defined as condition in which the cells in the thyroid gland have become cancerous.
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the Zhangqiu People's Hospital Ji'nan, higher tea consumption may have a protective effect on thyroid cancer, especially in Europe and America(1).
Epigallocatechin-3-gallate (EGCG), a major catechin in green tea, inhibited thyroid cancer cell proliferation and motility in associated to the loss of the initiation of metastasis for cancer progression(2) and to the suppression of EGFR/ERK pathway in binding to the receptor on the cell surface and cyclin B1/CDK1 complex for cell division(3).
(1) Association of tea consumption and the risk of thyroid cancer: a meta-analysis by Ma S1, Wang C2, Bai J1, Wang X1, Li C3.(PubMed)
(2) Epigallocatechin gallate inhibits growth and epithelial-to-mesenchymal transition in humanthyroid carcinoma cell lines by De Amicis F1, Perri A, Vizza D, Russo A, Panno ML, Bonofiglio D, Giordano C, Mauro L, Aquila S, Tramontano D, Andò S.(PubMed)
(3) Epigallocatechin-3-gallate induces growth inhibition and apoptosis of human anaplastic thyroidcarcinoma cells through suppression of EGFR/ERK pathway and cyclin B1/CDK1 complex by Lim YC1, Cha YY.(PubMed)
(4) 3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound inthyroid disease by Tadi K1, Chang Y, Ashok BT, Chen Y, Moscatello A, Schaefer SD, Schantz SP, Policastro AJ, Geliebter J, Tiwari RK(PubMed)
(5) 3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound inthyroid disease by Tadi K1, Chang Y, Ashok BT, Chen Y, Moscatello A, Schaefer SD, Schantz SP, Policastro AJ, Geliebter J, Tiwari RK.(PubMed)
(6) 3,3'-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferativedisease: a pilot study by Rajoria S1, Suriano R, Parmar PS, Wilson YL, Megwalu U, Moscatello A, Bradlow HL, Sepkovic DW, Geliebter J, Schantz SP, Tiwari RK.(PubMed)
(7) Antiproliferation and redifferentiation in thyroid cancer cell lines by polyphenol phytochemicals. by Kang HJ1, Youn YK, Hong MK, Kim LS.(PubMed)
(8) Resveratrol and its impact on aging and thyroid function by Duntas LH1.(PubMed)
(9) Resveratrol increases iodide trapping in the rat thyroid cell line FRTL-5 by Sebai H1, Hovsépian S, Ristorcelli E, Aouani E, Lombardo D, Fayet G.(PubMed)