The Curable Smoothie of Curcumin, Aloe Vera juice and Grape for Prevention and Treatment of Rosacea

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.

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The smoothie for prevention and treatment of  Rosacea 

Yield: 2 servings (about 8 ounces each)

1 1/2 cups blueberry

1 tsp curcumin

1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute

2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.

3. Serve immediately

The finding of a natural source for treatment of Rosacea  has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Rosacea is a chronic inflammatory condition with redness or blushing facial skin. According to the University of Louisville, licorice, green tea, pomegranate, turmeric may be sued for treatment of Rosacea, due to its powerful anti inflammatory effect(1).

Dr. Wu J said, ".....active ingredients, anti-inflammatory properties, clinical effects, and therapeutic potential(rosacea, atopic dermatitis, sensitive and irritated skin, drug-induced skin eruptions, and psoriasis) of colloidal oatmeal, feverfew, licorice, aloe vera, chamomile, and turmeric"(2).

Recent studies by some renowned institutions suggested that Curcumin(5), Aloe Vera juice(7) and blueberry(4) may be the next generation of ingredient extracted from natural sources for reduced risk and treatment of Rosacea.

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in blueberry and grape also exhibited anti inflammatory effect against pro inflammatory cytokines(3). According to the investigated the effect of resveratrol on skin lesion, in an atopic dermatitis (AD) mouse model, showed that the phytochemical inhibited the prto inflammatory pathways against skin diseases through modulating the HMGB1 protein expression, a cytokine mediator of inflammation(4).

Curcumin, is a major chemical constituent found in turmeric, which  is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia. According to the joint study lead by the Stony Brook University, the antioxidant inhibited two inflammatory diseases, periodontitis and rosacea, through inflammatory mediators expression(5).

In fact, Dr. Zhang Y and professors at the State University of New York at Stony Brook said, "Tetracyclines (TCs), (having uniquely modified curcumin as a "core" molecule), are known inhibitors of mammalian-derived MMPs, and non-antibiotic formulations of Doxycycline are FDA-approved to treat periodontitis and the chronic inflammatory skin disease, rosacea"(6).

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. According to the University of Pretoria, the herb has been used in treatment of skin disorders, through ts moisturizing and anti-inflammatory effects in modulating the IgE levels of mouse model of atopic dermatitis (AD)(7).

Dr. Benson KF and colleagues in the Aloe vera-based extract of Nerium oleander leaves against skin diseases, said, "NAE-8(®), a novel component of a commercial cosmetic product, showed beneficial antioxidant protection in several cellular models, without the induction of leukocyte activation and secretion of inflammatory cytokines"(8).

Taking altogether, The combination of Curcumin, Aloe Vera juice and Grape may offer the potential effect not only in prevention of the onset but also treatment of Rosacea.
 People who are at increased risk of Pyoderma gangrenosum are wise to drink at least one serving daily. People with  Rosacea, should drink the juice as much as they can, depending to the toleration of digestive system.

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References

(1) Innovations in natural ingredients and their use in skin care by Fowler JF Jr1, Woolery-Lloyd H, Waldorf H, Saini R.(PubMed)

(2) Anti-inflammatory ingredients by Wu J1.(PubMed)

(3) One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease by Tomé-Carneiro J1, Larrosa M, Yáñez-Gascón MJ, Dávalos A, Gil-Zamorano J, Gonzálvez M, García-Almagro FJ, Ruiz Ros JA, Tomás-Barberán FA, Espín JC, García-Conesa MT.(PubMed)

(4) Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice by Karuppagounder V, Arumugam S, Thandavarayan RA, Pitchaimani V, Sreedhar R, Afrin R, Harima M, Suzuki H, Nomoto M, Miyashita S,Suzuki K, Watanabe K.(PubMed)

(5) A novel chemically modified curcumin reduces severity of experimental periodontal disease in rats: initial observations by Elburki MS1, Rossa C2, Guimaraes MR2, Goodenough M1, Lee HM1, Curylofo FA2, Zhang Y3, Johnson F3, Golub LM1(PubMed)

(6) Design, synthesis and biological activity of new polyenolic inhibitors of matrix metalloproteinases: a focus on chemically-modified curcumins. by Zhang Y1, Gu Y, Lee HM, Hambardjieva E, Vranková K, Golub LM, Johnson F.(PubMed)

(7) A comparison of the leaf gel extracts of Aloe ferox and Aloe vera in the topical treatment of atopic dermatitis in Balb/c mice by Finberg MJ1, Muntingh GL1, van Rensburg CE2.(PubMed)